By Stewart W. Clarke
ISBN-10: 0407002650
ISBN-13: 9780407002654
Read Online or Download Aerosols and the Lung. Clinical and Experimental Aspects PDF
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Additional info for Aerosols and the Lung. Clinical and Experimental Aspects
Sample text
Cytochemical studies have shown that the secretory granules contain lipids which are bound to a non-lipid component (Azzopardi and Thurlbeck, 1969), phospholipids, protein and carbohydrate (Cutz and C o n e n , 1971). T h e presence of lipids has been confirmed by using r a d i o l a b e l e d precursors H - p a l m i t a t e and H - a c e t a t e (Petrik and Collet, 1974). , 1976). T h e presence of neutral glycoproteins in the secretory granules is still controversial. Histochemical studies indicate that the P A S positive material is a neutral glycoprotein (Azzopardi and Thurlbeck, 1969; Cutz and C o n e n , 1971), but recently Widdicombe and Pack (1982) concluded that glucose and glucosamine are not taken up by the Clara cells which is against glycoprotein synthesis.
T h e volume of mucus produced daily by a normal h u m a n tracheobronchial tree is not known with certainty. Based on studies in subjects with tracheostomy, the daily volume was found to be 7 and 2 1 m l (Toremalm, 1960). It is possible that this Tracheobronchial secretion 31 volume is an overestimation since the airways of these subjects are not entirely normal and the tracheostomy tube could be inducing reflex mucus hypersecretion. , 1977b). Material obtained from bronchial lavage is suitable for chemical analysis but unsuitable for rheological studies.
These cells are more numerous at first, but in small bronchioles Clara cells dominate the epithelium. Striking interspecies differences have been reported in their n u m b e r , distribution and presence of cytoplasmic organelles. Clara cells are found in a greater part of the bronchial tree of small compared to large animals (Cutz and C o n e n , 1971). T h e Clara cells are identified by the characteristic apical bulge into the lumen and the presence of electron-dense granules which in the h u m a n appeared mottled.
Aerosols and the Lung. Clinical and Experimental Aspects by Stewart W. Clarke
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